GABAB PAM for Chronic cough

Indicaton

Milestone: IND enabling studies ready to start in 2025* (Timings subject to financing / partnering)

We have selected a drug candidate to advance our own independent GABAB PAM program for the treatment of chronic cough.

This target is clinically validated with baclofen, an orthosteric agonist of GABAB, is used off label to treat chronic cough patients. However, baclofen’s use is limited by serious side-effects, short half-life and gradual loss of efficacy during chronic treatment. By more precisely targeting the GABAB receptor with a PAM we aim to have a best-in-class treatment with improved tolerability suitable for the chronic nature of this disease.

This indication has a significant unmet medical need and represents a solid commercial opportunity.
Subject to funding we plan to start IND enabling studies in 2025.

Therapeutic indications

Type of product

Small molecule

Table

Phase

Discovery

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