- 1998 Monoclonal antibodies Trastuzumab
Herceptin, Roche, breast cancer
- 1998 Interferon beta-1a
Rebif, Serono, multiple sclerosis
- 2001 Bosentan
Tracleer, Actelion, pulmonary arterial hypertension (PAH)
- 2003 Kinase inhibitors Imatinib
Gleevec, Novartis, cancer
- 2013 CRISPR-Cas9 gene editing
CRISPR Therapeutics using technology to treat genetic diseases
- 2013 Humanized anti-CD20 monoclonal antibody Obinutuzumab
Gazyva, Glycart/Roche, chronic lymphocytic leukaemia
- 2017 CAR-T cell therapy Tisagenlecleucel
Kymriah, Novartis, leukaemia
- 2019 Humanized single chain antibody anti-VEGF Brolucizumab
Beovu, Esbatech/Novartis, wet-AMD
- 2019 Gene therapy Onasemnogene abeparvovec-xioi
Zolgensma, Novartis, paediatric spinal muscular atrophy (SMA)
- 2021 Aducanumab
Aduhelm, Neuroimmune/Biogen, Alzheimer’s disease
- 2023 DDM Genomics and Multimodal platform
SOPHiA GENETICS hits milestone of One Million Genomic Profiles analyzed by the SOPHiA DDM™ platform
Most of these highlights were achieved in international collaboration and benefit patients around the world. They do not represent a comprehensive list but rather a selection that emphasizes the diversity of modalities that have been developed over time and the broad range of medical needs they help to address.